Police are appealing for public assistance to help locate missing man Stuart O'Connor.

The 51-year-old was last seen on Penny Avenue in Horsham about 5.45am on Tuesday 9 August.

He was wearing pants, work boots, maroon coloured beanie and was carrying a light blue sleeping bag.

Police and family are concerned for his welfare as he suffers from a medical condition.

Investigators have released an image of Stuart in the hope someone knows his whereabouts.

Stuart is about 190cm tall with long grey hair and a tanned complexion.

He is known to frequent the Natimuk, Horsham and Ballarat areas.

Anyone with information is urged to contact Horsham Police Station on 5382 9200.